Library containing 900 strains of microorganisms
An extraordinary trillions of microorganisms inhabit the human body compared to just 37 trillion human somatic cells, and notably, more than 70% of these microorganisms are anaerobic. We have succeeded in isolating and cultivating these enormous numbers of microorganisms and are constructing a library that will contain over 900 strains of microorganisms when completed. Recently, the relationship between diseases such as cancer, immune and digestive tract disorders and gut microorganisms (microbiota/microbiome) has been clarified, and research to elucidate the mechanisms and dynamics of the interaction between hosts and the microbiome is underway worldwide. We are using the technology such as metagenomics and bioinformatics of gut microbiome to search for new gut microorganisms as well as elucidating the functions of them in our libraries. This open innovation research is being pursued through scientific collaboration with academia and research institutes.
Open innovation research with academia
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|University/Research Institute||Researcher||Starting in||Research Topic|
|Graduate School of Agriculture, Kyoto University||Jun Ogawa
|Dec-10||Research of gut microbial metabolites' production|
|RIKEN Innovation Center||Yoshimi Benno||Apr-13||Cultivation of gut microbes and construction of their libraries|
|Tokyo University of Agriculture and Technology Graduate Schoool of Agriculture||Ikuo Kimura||Jan-15||Exploration of functionality of gut microbes and their metabolites|
|National Institutes of Biomedical Innovation, Health and Nutrition||Jun Kunisawa||Jan-17||Verification of health promotion effect of gut microbes and their metabolites|
|School of Medicine, Keio University||Hiroshi Itoh||Jan-17||Research toward the clinical application of gut microbial metabolites|
|Keio University Faculty of Pharmacy／RIKEN Center for Integrative Medical Sciences||Makoto Arita||Aug-17||Elucidation of biokinetics and matabolisms of gut microbes and their metabolites|
|Kobe University Graduate School of Medicine||Tomoya Yamashita||Sep-17||Research toward the clinical application ralated to gut microbes|
|Kobe University Graduate School of Medicine||Wataru Ogawa||Jan-18||Research toward the clinical application ralated to gut microbial metabolites|
|Laboratory of Immunology and Infection Control
The University of Tokyo
|Reiko Shinkura||Apr-19||Influence of microorganisms and their metabolites for immune system|
We offer a line of probiotics comprising seven original strains. We have developed unique stabilizing agents ensuring longer-lived probiotics and freeze-drying production for long-term preservation so that the activity of each type of microoganisms remains at the maximum for its human health benefits.
Enterococcus faecalis NT
This is a type of lactic acid bacteria living in human intestines. E.faecalis NT, shaped like small spheres, is easy to ingest for you in large quantities at one time. This beneficial microbe grows quickly, preventing the growth of harmful bacteria.
Lactobacillus brevis NTT001
These lactic acid bacteria were isolated from suguki pickle, a traditional fermented food in Kyoto. It activates natural killer (NK) cells, which attack virus and cancer cells, to enhance the human immune system.
Lactobacillus brevis NTM003
They were isolated from the canola pickle, a traditional fermented food in Kyoto. This microbe has been shown to prevent hepatic fat accumulation, decompose purines, and lower uric acid levels in animal study.
Leuconostoc mesenteroides NTM048
They were isolated from green peas and produces a large amount of sticky exopolysaccharide (Leucosaccharides). It induces the secretion of IgA antibodies, which prevent the invasion of viruses and pathogens. It has been verified that this microbe also regulates the immune balance and alleviates allergy symptoms.
Bifidobacterium longum NT
This is the most common beneficial microbe living in human intestines. Its numbers decrease as we age. It differs markedly from lactic acid bacteria in that it produces acetic acid as well as lactic acid, preventing the proliferation of harmful bacteria with its strong antibacterial activity. Recently it has been found that the acetic acid produced by it helps to antiobesity.
Bacillus natto NT
They are good germs isolated from natto (fermented soybeans). They form spores which are resistant to heat and acid and have a high probability of surviving to reach the intestines. Bacillus natto promotes the growth of bifidobacterium. It also produces dipicolinic acid, which has an antibiotic effect against Helicobacter pylori and Escherchia coli O-157.
Clostridium butyricum NT
Clostridium butyricum NT was isolated from human. Butyric acid produced by C. butyricum not only prevents the growth of harmful bacteria by acidifying the intestines but also stimulates the immune system, thus it reduces inflammation and allergic reactions.